Ibuprofen therapy

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Patient-reported outcomes of therapy with two brands of ibuprofen

OBJECTIVE To investigate patients' reported outcome following medication with two brands of 400 mg ibuprofen used to alleviate musculoskeletal pains. METHODS Adult peasant manual laborers (85) who met criteria were randomly assigned to receive either of the brands (A or B). Data on pain alleviation were gathered using the Short-Form McGill Pain Questionnaire (SF-MPQ), Visual Analogue Scale (V...

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Acquired Pelger-Huët anomaly associated with ibuprofen therapy.

Pelger–Huët anomaly (PHA) is a benign inherited condition characterized by hyposegmentation of the neutrophils nucleus and excessive chromatin clumping [1]. An acquired neutrophils dysplasia similar to PHA has been already described in hematological diseases [2,3] and in some clinical conditions, especially under certain drugs effect [4–9]. It has been known as acquired or pseudo Pelger–Huët an...

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Combined and alternating paracetamol and ibuprofen therapy for febrile children.

BACKGROUND Health professionals frequently recommend fever treatment regimens for children that either combine paracetamol and ibuprofen or alternate them. However, there is uncertainty about whether these regimens are better than the use of single agents, and about the adverse effect profile of combination regimens. OBJECTIVES To assess the effects and side effects of combining paracetamol a...

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Bioavailability of ibuprofen following oral administration of standard ibuprofen, sodium ibuprofen or ibuprofen acid incorporating poloxamer in healthy volunteers

BACKGROUND The aim of this study was to compare the pharmacokinetic properties of sodium ibuprofen and ibuprofen acid incorporating poloxamer with standard ibuprofen acid tablets. METHODS Twenty-two healthy volunteers were enrolled into this randomised, single-dose, 3-way crossover, open-label, single-centre, pharmacokinetic study. After 14 hours' fasting, participants received a single dose ...

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Hydrolysis of ibuprofen nitrile and ibuprofen amide and deracemisation of ibuprofen using Nocardia corallina B-276.

A novel application of whole cells of Nocardia corallina B-276 for the deracemisation of ibuprofen is reported. This microorganism successfully hydrolysed ibuprofen nitrile to ibuprofen amide, and ibuprofen amide to ibuprofen, using a suspension of cells in a potassium phosphate buffer solution (0.1 M, pH = 7.0). These results can be explained by the presence of NHase and amidase enzymes, but t...

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ژورنال

عنوان ژورنال: Arthritis & Rheumatism

سال: 1975

ISSN: 0004-3591,1529-0131

DOI: 10.1002/art.1780180417